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Holger Jaeschke Selected Research

Nonautoimmune Hyperthyroidism

10/2014A newly discovered TSHR variant (L665F) associated with nonautoimmune hyperthyroidism in an Austrian family induces constitutive TSHR activation by steric repulsion between TM1 and TM7.
3/2011Shared sporadic and somatic thyrotropin receptor mutations display more active in vitro activities than familial thyrotropin receptor mutations.
12/2010Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas.
1/2010Current standards, variations, and pitfalls for the determination of constitutive TSHR activity in vitro.

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Holger Jaeschke Research Topics

Disease

4Nonautoimmune Hyperthyroidism
10/2014 - 01/2010
2Congenital Hypothyroidism (Cretinism)
01/2022 - 01/2016
2Hyperthyroidism
01/2022 - 10/2018
2Thyroid Neoplasms (Thyroid Cancer)
12/2010 - 10/2007
1Goiter
10/2018
1Papillary Thyroid Cancer
10/2018
1Hypothyroidism
05/2018
1Thyroid Nodule (Nodule, Thyroid)
10/2007
1Graves Disease (Basedow Disease)
10/2007

Drug/Important Bio-Agent (IBA)

5Thyrotropin Receptors (Thyrotropin Receptor)IBA
10/2018 - 10/2007
2Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
01/2022 - 10/2018
2Thyroid HormonesIBA
10/2018 - 01/2016
2LigandsIBA
01/2010 - 10/2007
1CatecholaminesIBA
01/2022
1Hormones (Hormone)IBA
01/2022
1SteroidsIBA
01/2022
1Colloids (Colloid)IBA
10/2018
1Proteins (Proteins, Gene)FDA Link
05/2018
1TamoxifenFDA LinkGeneric
05/2018
1Protein Kinase CIBA
10/2007
1ThyroglobulinFDA Link
10/2007
1sodium-iodide symporter (sodium iodide symporter)IBA
10/2007

Therapy/Procedure

1Therapeutics
10/2007